Which Is The Right For You?
Reviewed by Dr Lucy NewtonWe've built the ultimate resource for figuring out whether Ozempic or Wegovy is the right fit for your personal situation.
We've analyzed over 2 million Reddit posts on real user experiences with Wegovy and Ozempic so you don't have to trawl through hundreds of posts finding the answers you want.
Side-by-side comparison based on 10,000+ Reddit discussions
| Feature | Ozempic | Wegovy | Source Notes |
|---|---|---|---|
| Typical Weight Loss | ~10% | 13.7% | SURMOUNT-5 (Wegovy 2.4mg) vs SUSTAIN trials (Ozempic 2.0mg in T2D) |
| Max Dose | 2mg weekly | 2.4mg weekly | Wegovy uses higher semaglutide dose for weight loss |
| Starting List Price | $968 | $1,349 | 2026 Novo Nordisk list prices (pre-discount) Learn more → |
| Self-Pay Cost | $850-$950 | $650-$1,349 | NovoCare self-pay programs available for Wegovy Learn more → |
| Insurance Coverage | Strong (T2D) | Moderate (Weight) | Diabetes indication significantly easier to cover |
| Cardiovascular Data | Proven Benefit | 20% MACE Reduction | SELECT trial confirmed Wegovy heart benefit Learn more → |
| Oral Option | Rybelsus (Daily) | Wegovy Pill (New) | Injectable vs Oral availability |
| Supply Status | Resolved | Improving | FDA shortage tracker Jan 2026 status Learn more → |
SURMOUNT-5 (Wegovy 2.4mg) vs SUSTAIN trials (Ozempic 2.0mg in T2D)
Wegovy uses higher semaglutide dose for weight loss
NovoCare self-pay programs available for Wegovy Learn more →
Diabetes indication significantly easier to cover
SELECT trial confirmed Wegovy heart benefit Learn more →
Injectable vs Oral availability
Data from the SUSTAIN vs STEP (Semaglutide 2.0mg vs 2.4mg) (Novo Nordisk / NEJM)
Ozempic and Wegovy contain the same active molecule (semaglutide). The primary difference is the approved dosage and indication. Ozempic maxes at 2.0mg for diabetes, while Wegovy goes to 2.4mg for weight loss. Head-to-head clinical data shows a clear 'dose-response' relationship for weight loss.
| Comparison Metric | Ozempic | Wegovy |
|---|---|---|
| Max Weight Loss (%) | ~10% (2.0mg) | 14.9% (2.4mg) |
| Lost >5% Body Weight | 68% | 86% |
| HbA1c Reduction | -2.1% | Not studied* |
| Cardiovascular Benefit | Proven | 20% MACE reduction |
| FDA Indication | Type 2 Diabetes | Weight Management |
"While both medications use semaglutide, Wegovy is slightly more effective for weight loss because it is prescribed at a 20% higher dose (2.4mg vs 2.0mg). However, for cardiovascular protection in diabetic patients, Ozempic remains the clinical standard. Wegovy's SELECT trial (20% reduction) is the gold standard for obesity-related heart health."
Results were statistically significant (p < 0.001) across all primary endpoints.
Latest verification performed January 2026.
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