Clinical Data & Patient Experiences
Last Updated: January 16, 2026 | Source: FDA Prescribing Information + Patient Discussion Analysis
Adverse reactions from SUSTAIN trials for type 2 diabetes.
| Adverse Reaction | Placebo | 0.5mg | 1mg |
|---|---|---|---|
| Nausea | 6.1% | 15.8% | 20.3% |
| Vomiting | 2.3% | 5.0% | 9.2% |
| Diarrhea | 1.9% | 8.5% | 8.8% |
| Abdominal Pain | 4.6% | 7.3% | 5.7% |
| Constipation | 1.5% | 5.0% | 3.1% |
Source: FDA Prescribing Information for Ozempic (semaglutide)
Analysis of 50,000+ posts from r/Ozempic, r/semaglutide (2023-2026).
Note: Patient-reported data is anecdotal. Not a substitute for clinical data.
Clinical: 15-20% depending on dose
Many describe nausea peaking 2-4 days post-injection, especially during dose increases.
"The first few weeks on 0.5 were rough. Now at 1mg and my body has adjusted."
— r/Ozempic user
Relief: Ondansetron, ginger, small frequent meals
Clinical: Listed as "eructation" 1-2.7%
The "sulfur burp" phenomenon is extensively discussed—burps that taste like rotten eggs.
"The egg burps were my warning sign before worse GI issues. Learned to recognize them."
— r/Ozempic user
Triggers: Fatty foods, eggs, dairy, overeating
Clinical: Not in trials; added post-marketing
Typically appears 3-6 months after starting, likely related to rapid weight loss (telogen effluvium).
"My dermatologist confirmed it's from the weight loss, not the medication itself."
— r/Ozempic user
Management: Adequate protein (60-80g/day), biotin, multivitamin
Medical Disclaimer: This content is for informational purposes only. Consult your healthcare provider.
Sources: FDA Prescribing Information, r/Ozempic community discussions
