Saxenda Side Effects

Clinical Data & Patient Experiences

FDA DataDaily Injection

Last Updated: January 16, 2026 | Source: FDA Prescribing Information + Patient Discussion Analysis

Clinical Trial Side Effects (FDA Data)

Adverse Reaction	Placebo	3mg
Nausea	13.8%	39.3%
Diarrhea	9.9%	20.9%
Constipation	8.5%	19.4%
Vomiting	3.9%	15.7%
Dyspepsia	2.7%	9.6%

Source: FDA Prescribing Information for Saxenda (liraglutide 3mg)

What Patients Are Experiencing

Analysis of posts from r/Saxenda, r/liraglutide (2023-2026).

Note: Patient-reported data is anecdotal. Not a substitute for clinical data.

Daily Injection Considerations

Unlike weekly GLP-1s, Saxenda requires daily injections. Some find this helps manage side effects (can skip a day if severe), others find it burdensome.

"Daily shots felt like a lot at first, but I actually prefer it—I can skip a day if I'm feeling rough."
— r/Saxenda user

Nausea Patterns

Clinical: 39.3%

Nausea is most common during titration. The 5-week dose escalation helps but many still struggle.

Relief: Slower titration, ginger, small meals, taking at bedtime

When to Call Your Doctor

• Severe abdominal pain (possible pancreatitis)
• Signs of gallbladder problems
• Rapid heart rate or palpitations
• Unable to keep liquids down 24+ hours

Medical Disclaimer: This content is for informational purposes only. Consult your healthcare provider.

Sources: FDA Prescribing Information, r/Saxenda community discussions